Glossary

Glossary

A
Alternative proteins

Protein alternatives to animal proteins traditionally obtained from the meat or milk of higher farm animals; can come from plant sources (e.g. pea protein), from microbial biomass (e.g. yeast) or from targeted microbial fermentation (precision fermentation). They can also come from protein-rich edible insects or from meat-like tissues cultivated in the laboratory ("clean meat"); the aim of producing alternative proteins is to avoid factory farming and the associated environmental destruction and to reduce CO2 emissions.

Animal-identical" alternative proteins are proteins of animal origin that are produced by microorganisms while retaining their biochemical structure and functionality. Examples include milk proteins, egg proteins or proteins for the production of meat substitutes. In the case of other proteins (e.g. enzymes, structural proteins), the protein structure is often deliberately and specifically modified in the bioprocess in order to improve properties for later use (e.g. enzyme activity) or to eliminate them (e.g. instability)

Aurase®

Aurase® is an enzymatic substance developed by BRAIN Biotech for the cleansing of chronic wounds. SolasCure Ltd., which was founded with the participation of BRAIN Biotech, is working on the approval of the medical substance.

B
Bioactive (natural) compounds

Are used to develop products in the food, beverage, skin care, cosmetics and chemical industries. At the BRAIN Biotech BioScience site in Potsdam (AnalytiCon Discovery), experts work in the field of natural product chemistry and carry out active ingredient screenings, among other things. Over the years, the company has built up an extensive library of bioactive substances (including small molecules). The active ingredient deucrictibant (formerly PHA121) discovered there is currently being developed into a drug by the Swiss company Pharvaris.

Bio-based products

Bio-based products are goods manufactured from renewable raw materials

Biocatalysts Ltd. und Biocatalysts Inc.

Companies of the BRAIN Biotech Group based in UK (headquarters in Cardiff, Wales) and in US (Illinois); global distributor network e.g. Korea, Australia, New Zealand. Key player in the specialty enzyme business

BioIncubator

This business segment includes BRAIN Biotech's own disruptive development projects and partner projects for "new business" with high commercial potential; the value creation options include spin-offs, licenses, milestone payments, production and sales.

Biocatalysis, industrial

Biocatalysis is the use of a biological system to increase the rate of a chemical reaction. Such a biological system may be enzymes or cells. "Industrial biocatalysis" describes the process on an industrial scale. Raw materials can be efficiently and sustainably converted into desired products.

Biocatalysts

Enzymes that act as catalysts to accelerate (bio)chemical reactions

Biologisation of industry

Application of biological processes in an industrial setting with the aim of creating a more sustainable economy

BioProducts

One of the three business segments of BRAIN Biotech AG. It comprises the development and marketing of proprietary products, including enzymes, along the value chain.

Bioprocesses / Bioprocess development

Processes that use living cells (e.g., bacteria or fungi) or molecules produced by them (e.g., enzymes) to obtain specific products. Bioprocess development involves determining the optimal "design space" for a particular microbial product with the desired yield and purity. Efficient and cost-effective bioprocess development is necessary for new biotechnological production processes to emerge as competitive alternatives to existing processes or products.

Biorefinery

Technology for the sustainable processing of biomass into marketable products (e.g. food, feed, materials, chemicals) and energy (fuels, electricity, heat). Integrated biorefineries combine various such technologies with the aim of greater flexibility and cost reduction. Integrated biorefineries facilitate the use of byproducts and waste, and enable the production of high-quality products (e.g. fine chemicals) combined with low-quality products (e.g. bioenergy).

BioScience

One of the three business segments of BRAIN Biotech AG. The segment comprises research-intensive, customer-specific development projects and collaborations.

Biotechnology

Application-oriented sub-sector of biology; includes insights and methods from microbiology, genetics, biochemistry, technical chemistry and process engineering; utilizes biological processes e.g. for industrial applications

BRAIN Biotech libraries

In-house collection consisting of around 53,000 comprehensively characterized microorganisms (including “chassis microorganism” strains for the development of production organisms) and the BRAIN libraries:

Enzyme library: up to 500 isolated and pre-characterized enzymes and DNA encoding enzymes introduced into expression vectors.

Metagenome library: screenable DNA library containing metagenomes from different habitats; collection serves to identify previously uncharacterized enzymes and metabolic pathways.

Compound Library: Natural product collection with sub-collections for specific, well-characterized sub-sub-substance groups.

BRAIN Bioarchive

The company's own collection, consisting of around 53,000 comprehensively characterized microorganisms (including "chassis microorganism" strains for the development of production organisms) as well as an enzyme and a metagenome library

C
CRISPR

 

Abbreviation for: Clustered Regularly Interspaced Short Palindromic Repeats

CRISPR-Cas

CRISPR-Cas (= CRISPR/Cas) is the name of a method with which molecular biologists can cut DNA in a targeted and precise manner. The so-called "gene scissors" (for genome editing) thus enable the selective insertion, removal or modification of individual DNA segments in the living organism. The method offers biotechnologists the possibility to carry out targeted mutations and thus, for example, to optimize the metabolic performance of microbial production organisms within a short time.

Biochemically, the CRISPR-Cas complex consists of the CRISPR-associated protein "Cas" with the function of a DNA-cutting protein (belongs to the enzyme class of nucleases), as well as a piece of RNA, the so-called guide RNA, which directs the Cas protein to the site on the DNA to be cut.

The acronym "CRISPR" stands for „Clustered Regularly Interspaced Short Palindromic Repeats”, a repetitive region on the genome of the bacterium where this DNA region was initially discovered and by which CRISPR systems can be recognized. CRISPR-Cas systems are derived from a natural mechanism that bacteria use to protect themselves from harmful viruses.

In basic research, CRISPR-Cas technology is already being used in a wide range of applications. However, the unclear patent situation specifically for the CRISPR/Cas9 system often prevents its use in companies, as there are as yet unforeseeable patent risks, as well as expensive licensing fees to be paid. For this reason, the Group´s R&D site BRAIN Biotech Zwingenberg has developed its own variants of the CRISPR-Cas scissors, BEC and BMC.

D
Disruptive innovations

Innovations that can lead to business models or technologies being replaced

DNA

Deoxyribonucleic acid: biomolecule that carries genetic information (genes)

DNK

Abbreviation for the German Sustainability Code (Deutscher Nachhaltigkeitskodex); BRAIN Biotech has published a declaration in relation to the German Sustainability Code. The entry in the DNK database supports BRAIN Biotech’s sustainability reporting activities and provides transparency in relation to the company’s development

E
Enzymes

Proteins that accelerate biochemical reactions in their function as biocatalysts; play an important role in the development of biobased products; BRAIN Biotech identifies and develops optimized enzymes and biocatalysts for complex process and application requirements

F
Fermented food

Foods and beverages that have undergone controlled microbial growth and fermentation

FRESCO

BRAIN Biotech development program for freshness and product stability utilizing natural bioactive substances; suitable for the food and feed industry, for medical products, paints, cleaning agents and other household products.

G
Genome editing

Targeted modification of DNA using molecular biology techniques

Giga-bp DNA

DNA Length of a DNA sequence, indicated by the number of base pairs (1 Giga bp = 1,000,000,000 base pairs); common metagenomics measure

GMO

Genetically modified organisms

GRAS status

"Generally Regarded as Safe status": declaration of safety for the use of substances (e.g. microorganisms) to manufacture foodstuffs; GRAS organisms can be utilized without restriction in biotechnological production

Green Mining

Sustainable mining, e.g. ore treatment to extract gold, silver or copper using microorganisms rather than chemicals

H
Habitat

An organism’s natural environment

I
Industrial biotechnology

Also known as white biotechnology; drives innovation for a paradigm shift away from petroleum-based towards biological processes and bioeconomy products

K
M
Metagenome

Genomic information present in the entirety of all microorganisms of a specific community; BRAIN Biotech AG owns more than 40 metagenome libraries that contain genomic information on millions of new enzymes and metabolic pathways from previously uncultivable organisms

Metagenomics

Genomic analysis of a community of organisms by gene sequencing; genetic material is extracted, sequenced and analyzed directly from environmental samples, which saves the previous cultivation of microorganisms

Microorganism

Microscopically small unicellular or multicellular organisms, e.g. bacteria, algae, fungi or viruses

P
Peptides

Linear, sometimes ring-shaped chain of molecules consisting of two or more amino acids; long polypeptide chains are called proteins.

Precision fermentation

Further development of classic fermentation with the help of molecular biology and bioinformatics; fermentable organisms such as bacteria, yeasts or fungi are developed into production microorganisms ("cell factories") so that they produce a specific protein (or another molecule) in high quantities and purity and with specific properties. This typically requires the targeted, precise modification of the microorganism's genome - e.g. using genome editing or the introduction of genetic instructions - and the development of sophisticated fermentation processes. Proteins that are produced by precision fermentation and subsequently purified are, for example, enzymes, alternative proteins (see alternative proteins) or structural proteins for various industries.

Product sales at the BRAIN Biotech Group

Sales of products (manily enzymes) in the form of merchandise, technologies or biotechnological system solutions; can be achieved via the BRAIN Biotech Group’s direct B2B business or through joint product developments with industrial partners and corresponding licensing agreements; scalable-product business option offered by the BRAIN Biotech Group (see also R&D cooperation partnerships)

Postbiotics

Non-viable bacterial products or metabolic by-products of probiotic microorganisms that develop biological activity in the host. Are used, for example, in cosmetics.

Prebiotics

Food or dietary supplement containing an ingredient (indigestible) that selectively stimulates the growth and/or activity of indigenous bacteria.

Probiotics

Live microorganisms which, when used adequately, exert a health-promoting effect on humans and animals. Have been used for intestinal health in the food sector for over 50 years; new areas of application include cosmetics, agricultural or household products.

Precision probiotics

Probiotics optimized for performance and/or safety using nonGMO processes (e.g., natural evolution and targeted genome editing without the use of foreign DNA).

Protein engineering

In the process of protein engineering, proteins (e.g. enzymes) are constructed and optimized for specific purposes. The approach is either via so-called "rational design" (targeted mutagenesis, possible with existing knowledge of protein structure) or "directed evolution" (mimics natural evolution and requires no prior knowledge of protein structure).

S
SDGs-UN

United Nations Sustainable Development Goals

Specialty chemicals

Specific chemical products with a broad range of activities on which a large number of other industrial sectors depend

Stage-gate process

Standardized process model for developing product innovations with the aim of assuring process quality

Synthetic biology

Area of biology in which organisms are modified to develop new, useful abilities

Tailor made solutions (TMS)

Dedicated contract R&D programs for the development of tailor-made solutions for industry

U
Urban mining

Sustainable extraction of valuable substances from secondary raw materials and waste flows in order to retain them in value chains in the long term.

W
White Biotechnology

Includes the application of modern biotechnology in industrial production processes. Chemical starting materials are converted by enzymes and cells into products suitable for further processing. Also known as industrial biotechnology